For us women, the journey of aging can be both inspiring and challenging. It is a time of self-discovery, resilience and accepting the wisdom that comes with time. However, concerns about aging, both external and internal, often linger in our minds. The good news is that advances in genetic testing can provide valuable insights into our biology, helping us make informed decisions about our health and well-being as we navigate the beautiful journey of aging.
Unraveling our genes
Our genes hold the key to understanding our unique biology. Genetic testing, once reserved for medical diagnoses, has now evolved into a powerful tool for preventive healthcare. By unlocking the secrets encoded in our DNA, we gain a deeper understanding of our genetic makeup, which influences how we age.
Skin changes
Skin changes are one of the most visible signs of aging. This affects several properties of the skin such as hydration, elasticity and антиоксидантен капацитет. They play a key role in the skin aging process.
Skin aging is a complex process influenced by hereditary and environmental factors. Recent studies on twins have revealed that up to 60% of the variation in skin aging between individuals can be attributed to genetic factors, while the remaining 40% is due to non-genetic factors.
The good news is that through genetic testing, we can understand this 60% predisposition, which is a collection of multiple polymorphisms associated with certain skin properties, and get advice for personalized skin care and anti-aging therapies.
The report Skin and Beauty is aimed at exactly that. In it you will find a personal analysis of your predisposition, which is 60% of the causes of aging of your skin. You'll also find personalized recommendations for the best care.
As we have understood so far, the skin breaks down progressively (ages) as a result of external and internal factors. The significant changes underlying the process are:
Oxidative damage, for example, arise as a result of metabolic generation or sun exposure and lead to loss of dermal cells and the extracellular matrix. Although the elastic proteins in the matrix are long-lived, they also accumulate changes. This leads to the degeneration of the glycolipids, which in turn leads to a serious loss of water in the skin, because the glycolipids maintain the hydration of the skin.
Let's take a look into elasticity in people of different ethnicities and different genders, we see clear evidence of a genetic influence on skin aging. Wrinkles in Asians usually appear later and are significantly less than in Europeans.
Here isan example of how different genetic variants водят до различно ниво на еластичност на кожата ви:
Mutations in the gene of elasticity (ELN) can lead to conditions such as cutis laxa, characterized by loose and loose skin.
Collagen is another important protein in the skin that contributes to its strength and elasticity. The mutations in the collagen genes, such as COL1A1, COL1A2 and COL3A1, can affect the structural integrity of the skin.
Mutations in the gene fibrillin-1 (FBN1) are associated with certain connective tissue diseases that can affect skin elasticity.
Incorrectly selected care products can also significantly contribute to the loss of skin elasticity. In order not to search for the right product by trial and error, a DNA analysis can be done and the specific needs of the skin can be understood.
Here isan example of how different genetic variants cause different levels of hydration and the appearance of wrinkles.
Variations in the FLG gene lead to a loss of filaggrin protein and can lead to dry skin that can feel uncomfortable and can also be a factor in accelerated wrinkle development.
Difference between men's and women's skin
On the other hand, the physiological differences between men and women also emphasize the role of genetics for skin aging. For example, men's skin is more sensitive to environmental aggressors, especially exposure to ultraviolet light.
Литература:
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085290/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583889/
- https://selfdecode.com/app/article/flg-allergies/